Chang, Michael:Identifying Novel DNA Damage Response Genes Using Functional Genomics
- Paperback 2013, ISBN: 9783639701159
[ED: Softcover], [PU: Scholar's Press], DNA damage is a fairly common event and, if left unrepaired, can lead to genomic instability, a hallmark of cancer cells. My Ph.D. work, described … More...
[ED: Softcover], [PU: Scholar's Press], DNA damage is a fairly common event and, if left unrepaired, can lead to genomic instability, a hallmark of cancer cells. My Ph.D. work, described in this thesis, has focused primarily on elucidating how cells combat DNA damage to maintain genomic integrity. To fully understand the DNA damage response, it is important that all the components required for this process be identified. To this end, I took functional genomic approaches using the yeast Saccharomyces cerevisiae to identify genes required for coping with DNA damage. Specifically, I conducted a screen to identify genes required for resistance to a DNA damaging agent, methyl methanesulfonate. Using genome-wide genetic interaction screens, I helped identify ELG1, deletion of which causes DNA replication defects, genomic instability, and an inability to properly recover from DNA damage during S phase. I also used two-dimensional hierarchical clustering of synthetic genetic interaction data determined by large-scale genetic network analysis to identify RMI1, which encodes a new member of the highly conserved Sgs1-Top3 complex that is an important suppressor of genomic instability.
2013. 156 S. 220 mm
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Michael Chang:Chang, M: Identifying Novel DNA Damage Response Genes Using
- Paperback 2013, ISBN: 9783639701159
DNA damage is a fairly common event and, if left unrepaired, can lead to genomic instability, a hallmark of cancer cells. My Ph.D. work, described in this thesis, has focused primarily on… More...
DNA damage is a fairly common event and, if left unrepaired, can lead to genomic instability, a hallmark of cancer cells. My Ph.D. work, described in this thesis, has focused primarily on elucidating how cells combat DNA damage to maintain genomic integrity. To fully understand the DNA damage response, it is important that all the components required for this process be identified. To this end, I took functional genomic approaches using the yeast Saccharomyces cerevisiae to identify genes required for coping with DNA damage. Specifically, I conducted a screen to identify genes required for resistance to a DNA damaging agent, methyl methanesulfonate. Using genome-wide genetic interaction screens, I helped identify ELG1, deletion of which causes DNA replication defects, genomic instability, and an inability to properly recover from DNA damage during S phase. I also used two-dimensional hierarchical clustering of synthetic genetic interaction data determined by large-scale genetic network analysis to identify RMI1, which encodes a new member of the highly conserved Sgs1-Top3 complex that is an important suppressor of genomic instability. Buch (fremdspr.) Michael Chang Taschenbuch, Sps, 31.10.2013, Sps, 2013<
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Michael Chang:Identifying Novel DNA Damage Response Genes Using Functional Genomics
- Paperback 2013, ISBN: 3639701151
[EAN: 9783639701159], Neubuch, [PU: Scholars\\' Pres], BIOLOGIE DNA MOLECULAR BIOLOGY GENETICS YEAST REPAIR DAMAGE RESPONSE FUNCTIONAL GENOMICS, Dieser Artikel ist ein Print on Demand Art… More...
[EAN: 9783639701159], Neubuch, [PU: Scholars\\' Pres], BIOLOGIE DNA MOLECULAR BIOLOGY GENETICS YEAST REPAIR DAMAGE RESPONSE FUNCTIONAL GENOMICS, Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Chang MichaelMichael Chang is currently an Assistant Professor at the European Research Institute for the Biology of Ageing within the University of Groningen and the University Medical Center Groningen (the Netherlands). His researc., Books<
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Michael Chang:Identifying Novel DNA Damage Response Genes Using Functional Genomics
- First edition 2013, ISBN: 9783639701159
Paperback
[ED: Kartoniert / Broschiert], [PU: Scholars Press], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Chang MichaelMichael … More...
[ED: Kartoniert / Broschiert], [PU: Scholars Press], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Chang MichaelMichael Chang is currently an Assistant Professor at the European Research Institute for the Biology of Ageing within the University, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Taschenbuch, 156, [GW: 250g], 1. Auflage, Banküberweisung, PayPal<
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Chang, Michael:Identifying Novel DNA Damage Response Genes Using Functional Genomics
- new book 2013, ISBN: 3639701151
Kartoniert / Broschiert, mit Schutzumschlag 11, [PU:Scholars' Press]
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