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G-Quadruplex DNA - Peter Baumann
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G-Quadruplex DNA - hardcover

2009, ISBN: 9781588299505

Methods and Protocols, Buch, Hardcover, 2010 ed. Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the developm… More...

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ISBN: 9781588299505

Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quart… More...

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G-Quadruplex DNA - hardcover

ISBN: 9781588299505

Hardback, [PU: Humana Press Inc.], In this authoritative book, experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular r… More...

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G-Quadruplex DNA - Paperback

2010, ISBN: 9781588299505

*G-Quadruplex DNA* - Methods and Protocols. Auflage 2010 / gebundene Ausgabe für 160.49 € / Aus dem Bereich: Bücher, Wissenschaft, Biologie Medien > Bücher nein Buch (gebunden) Hardcover;… More...

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G-Quadruplex DNA - Peter Baumann
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Peter Baumann:
G-Quadruplex DNA - hardcover

2009, ISBN: 9781588299505

Methods and Protocols, Buch, Hardcover, 2010 ed. [PU: Humana Press Inc.], Humana Press Inc., 2009

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G-Quadruplex DNA
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9781588299505


Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.

Details of the book - G-Quadruplex DNA


EAN (ISBN-13): 9781588299505
ISBN (ISBN-10): 1588299503
Hardcover
Paperback
Publishing year: 2010
Publisher: Humana Press
276 Pages
Weight: 0,804 kg
Language: eng/Englisch

Book in our database since 2009-08-21T17:03:19-04:00 (New York)
Detail page last modified on 2024-02-29T11:12:54-05:00 (New York)
ISBN/EAN: 9781588299505

ISBN - alternate spelling:
1-58829-950-3, 978-1-58829-950-5
Alternate spelling and related search-keywords:
Book author: peter baumann, peter baum
Book title: dna

Information from Publisher

Author: Peter Baumann
Title: Methods in Molecular Biology; G-Quadruplex DNA - Methods and Protocols
Publisher: Humana; Humana Press
276 Pages
Publishing year: 2009-12-18
Totowa; NJ; US
Printed / Made in
Language: English
160,49 € (DE)
164,99 € (AT)
177,00 CHF (CH)
POD
XII, 276 p.

BB; Hardcover, Softcover / Biologie/Biochemie, Biophysik; Biochemie; Verstehen; DNA; Drug development; G-quartet formation and dynamics; Guanine bases; Molecular recognition; Oligonucleotides; Telomerase activity; microscopy; molecular biology; transcription; Biochemistry; Cell Biology; Medical Genetics; Zellbiologie (Zytologie); Genetik, Medizin; EA; BC

G-Quadruplexes: From Guanine Gels to Chemotherapeutics.- Molecular Modeling and Simulation of G-Quadruplexes and Quadruplex-Ligand Complexes.- Computational Approaches to the Detection and Analysis of Sequences with Intramolecular G-Quadruplex Forming Potential.- Preparation of G-Quartet Structures and Detection by Native Gel Electrophoresis.- Biochemical Techniques for the Characterization of G-Quadruplex Structures: EMSA, DMS Footprinting, and DNA Polymerase Stop Assay.- Real-Time Observation of G-Quadruplex Dynamics Using Single-Molecule FRET Microscopy.- Sedimentation Velocity Ultracentrifugation Analysis for Hydrodynamic Characterization of G-Quadruplex Structures.- 2-Aminopurine as a Probe for Quadruplex Loop Structures.- Assessing DNA Structures with 125I Radioprobing.- Monitoring the Temperature Unfolding of G-Quadruplexes by UV and Circular Dichroism Spectroscopies and Calorimetry Techniques.- Probing Telomeric G-Quadruplex DNA Structures in Cells with In Vitro Generated Single-Chain Antibody Fragments.- Detection of G-Quadruplexes in Cells and Investigation of G-Quadruplex Structure of d(T2AG3)4 in K+ Solution by a Carbazole Derivative: BMVC.- Isolation of G-Quadruplex DNA Using NMM-Sepharose Affinity Chromatography.- Quantifying Interactions Between G-Quadruplex DNA and Transition-Metal Complexes.- G4-FID: A Fluorescent DNA Probe Displacement Assay for Rapid Evaluation of Quadruplex Ligands.
Includes coverage of a wide range of methodologies to study G-quadruplex structures Provides detailed protocols which ensure successful re-recreation of experimental procedures Supplies step-by-step instructions in order to enable researchers to set up their own high throughput screens for G-quadruplex ligands Explores computational approaches for the detection of G-quadruplex-forming structures Examines state of the art physical, chemical, and biological methods Contains tricks of the trade and valuable troubleshooting advice Includes supplementary material: sn.pub/extras

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