11, ISBN: 9781441906397

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histon… More...

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer's disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or ag Adult, Medical Science, Epigenetics of Aging~~ Trygve Tollefsbol~~Adult~~Medical Science~~9781441906397, en, Epigenetics of Aging, Trygve Tollefsbol, 9781441906397, Springer, 11/11/2009, , , , Springer, 11/11/2009<

ISBN: 9781441906397

This seminal work covers the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging. It covers the mos… More...

This seminal work covers the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging. It covers the most recent advances that impact the longevity of living organisms.; PDF; Scientific, Technical and Medical > Pre-clinical medicine: basic sciences > Human reproduction, grow, Cambridge Scholars Publishing<

2009, ISBN: 9781441906397

[ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Springer-Verlag]

2009, ISBN: 9781441906397

eBooks, eBook Download (PDF), 2010, [PU: Springer New York], Springer New York, 2009

2009, ISBN: 9781441906397

2010, eBook Download (PDF), eBooks, [PU: Springer New York]