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Statistics in Clinical Vaccine Trials
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Statistics in Clinical Vaccine Trials - new book

ISBN: 9783642146909

This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The bo… More...

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Statistics in Clinical Vaccine Trials - Jozef Nauta
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Jozef Nauta:

Statistics in Clinical Vaccine Trials - hardcover

2010, ISBN: 3642146902

[EAN: 9783642146909], Used, good, [PU: Springer], Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May not contain Access Codes or Supplements. May be ex-library. S… More...

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Jos Nauta:
Statistics in Clinical Vaccine Trials - hardcover

2011

ISBN: 9783642146909

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Statistics in Clinical Vaccine Trials - Nauta, Jos
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Nauta, Jos:
Statistics in Clinical Vaccine Trials - hardcover

2010, ISBN: 3642146902

Gebundene Ausgabe Impfung, Mathematik / Statistik, Stochastik, Wahrscheinlichkeitsrechnung, Pharmakologie, mit Schutzumschlag neu, [PU:Springer-Verlag GmbH]

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Jozef Nauta (Author):
Statistics in Clinical Vaccine Trials - hardcover

2010, ISBN: 9783642146909

Hard cover, New in new dust jacket., Heidelberg |London, [PU: Springer Berlin Heidelberg]

Shipping costs: EUR 3.52 Blackwell's

Details of the book
Statistics in Clinical Vaccine Trials

This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book's scope is practical rather than theoretical. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the statistical methodology. Many real-life examples and SAS codes are presented, making application of the methods straightforward. Topics discussed include maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of equivalence and non-inferiority immunogenicity trial data, analysis of data from vaccine field efficacy trials (including data from studies with recurrent infection data), fitting protection curves to data of challenge or field efficacy studies, and the analysis of vaccine safety data.

Details of the book - Statistics in Clinical Vaccine Trials


EAN (ISBN-13): 9783642146909
ISBN (ISBN-10): 3642146902
Hardcover
Publishing year: 2010
Publisher: Springer-Verlag GmbH
153 Pages
Weight: 0,413 kg
Language: eng/Englisch

Book in our database since 2009-01-26T17:11:03-05:00 (New York)
Detail page last modified on 2019-10-12T17:32:48-04:00 (New York)
ISBN/EAN: 9783642146909

ISBN - alternate spelling:
3-642-14690-2, 978-3-642-14690-9


Information from Publisher

Author: Jozef Nauta
Title: Statistics in Clinical Vaccine Trials
Publisher: Springer; Springer Berlin
153 Pages
Publishing year: 2010-10-24
Berlin; Heidelberg; DE
Printed / Made in
Weight: 0,930 kg
Language: English
96,29 € (DE)
98,99 € (AT)
106,50 CHF (CH)
Not available, publisher indicates OP

BB; Book; Hardcover, Softcover / Mathematik/Wahrscheinlichkeitstheorie, Stochastik, Mathematische Statistik; Wahrscheinlichkeitsrechnung und Statistik; Verstehen; Mathematik; Vaccines; Statistics; Clinical Trials; Vaccines; Statistics; Clinical Trials; B; Statistics, general; Mathematics and Statistics; BC; EA; BB

Basic Concepts of Vaccine Immunology.- Humoral and Cellular Immunity.- Standard Statistical Methods for the Analysis of Immunogenicity Data.- Antibody Titres and Two Types of Bias.- Adjusting for Imbalance in Pre-vaccination State.- Vaccine Equivalence and Non-Inferiority Immunogenicity Trials.- Vaccine Field Efficacy Trials.- Correlates of Protection.- Safety of Vaccines.- Appendices: SAS and Floating Point Format for Calculated Variables.- Closed-Form Solutions for the Constrained ML Estimators Ro.- Simulation Results on Jewell’s Correction for the Rate Ratio.- Proof of Inequality.- A Generalized Worst-Case Sensitivity Analysis for a Single Seroresponse Rate for Which the Confidence Interval Must Fall Above a Pre-Specified Bound.
- First comprehensive text on the current state of the statistical methodology for clinical vaccines trials - Many worked-out real-life examples - SAS codes for the more complex examples provided; - First comprehensive text on the current state of the statistical methodology for clinical vaccines trials - Many worked-out real-life examples - SAS codes for the more complex examples provided

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