Chemical Mutagens - new book

EAN (ISBN-13): 9781461566250
Publishing year: 2012
Publisher: Springer US

Book in our database since 2015-11-26T21:11:26-05:00 (New York)
Detail page last modified on 2024-02-06T12:02:23-05:00 (New York)
ISBN/EAN: 9781461566250

ISBN - alternate spelling:
978-1-4615-6625-0
Alternate spelling and related search-keywords:
Book author: frédéric alexander, serres, frederick

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Information from Publisher

Author: Frederick J. de Serres; Alexander Hollaender
Title: Chemical Mutagens - Principles and Methods for Their Detection
Publisher: Springer; Springer US
497 Pages
Publishing year: 2012-12-06
New York; NY
Language: English
82,38 € (DE)
84,70 € (AT)
106,50 CHF (CH)
Available
XXVI, 497 p.

EA; E107; eBook; Nonbooks, PBS / Medizin/Klinische Fächer; Genetik, Medizin; Verstehen; DNA; Mamma; Mitose; Nitrat; Nitrit; amino acid; biology; chromosome; metabolism; mouse; mutagen; protein; C; Medical Genetics; Bioorganic Chemistry; Atomic, Molecular and Chemical Physics; Veterinary Science; Protein Biochemistry; Biomedical and Life Sciences; Organische Chemie; Biochemie; Atom- und Molekularphysik; Tiermedizin; BB

1 Effects of Chemicals on Chromosome-Aberration Production in Male and Female Germ Cells.- 1. Introduction.- 2. Methods of Detecting Chromosome Aberrations Induced in Germ Cells.- 3. Male Germ Cells.- 4. Female Germ Cells.- 5. Interpretations and Conclusions.- 6. References.- 2 The Use of Immunological Techniques to Detect Cells of Rare Genotype.- 1. Introduction.- 2. Isolation of Antibodies Suitable for Detecting Mutants: Antibodies to Single and Multiple Amino Acid Differences in Proteins.- 3. Detection of Mutants with the Help of Antibodies.- 4. Conclusion.- 5. References.- 3 Metabolic Activation Systems in Vitro for Carcinogen/Mutagen Screening Tests.- 1. Introduction.- 2. Common Pathways for the Activation and Detoxification of Carcinogens/Mutagens.- 3. Subcellular Metabolic Activation Systems: Some General Remarks.- 4. Cellular Metabolic Activation Systems.- 5. Combination of in Vivo—in Vitro Screening Tests of Carcinogens/Mutagens: Recent Developments.- 6. Problems in the Extrapolation of Data Obtained in Vitro to the Intact Mammalian Organism.- 7. Conclusions.- 8. References.- 4 Microbial Metabolism of Environmental Chemicals to Mutagens and Carcinogens.- 1. Introduction.- 2. Definition of a Compound as a Promutagen.- 3. Chemicals That Can Be Activated to Environmental Mutagens and Carcinogens by Microorganisms.- 4. Role of the Intestinal Microflora in the Formation of Mutagens and Carcinogens.- 5. Short-Term Test Systems and the Role of Microorganisms in the Metabolism of Chemicals into Mutagens: Conclusions.- 6. Summary.- 7. References.- 5 Short-Term Tests for Chemicals That Promote Aneuploidy.- 1. Introduction.- 2. Test Systems.- 3. Discussion.- 4. References.- 6 Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology.- 1. Introduction.- 2. MajorSources of Human Exposure.- 3. Flow in Humans.- 4. Suspected Health Consequences.- 5. Reduction of Exposure.- 6. Summary.- 7. References.- 7 The Relation between Reaction Kinetics and Mutagenic Action of Monofunctional Alkylating Agents in Higher Eukaryotic Systems: Interspecies Comparisons.- 1. Introduction.- 2. Mechanism of Action of Alkylating Agents.- 3. Reaction of Alkylating Agents with DNA and Proteins.- 4. Response to Alkylating Agents.- 5. Interspecies Comparisons.- 6. Conclusions.- 7. References.- 8 The Human Leukocyte Test System.- 1. Introduction.- 2. Some Early Events during Human Leukocyte Stimulation...- 3. DNA Synthesis, Mitosis, and the Diversity of the Culture System.- 4. Differences in Mutagen Sensitivity of Leukocyte Subpopulations?.- 5. Fate of Chromosomal Damage during Successive Cell Cycles.- 6. Selected Examples of in Vivo Investigations with Human Leukocytes.- 7. Appendix: Standard Protocol for Human Leukocyte Culture Preparation.- 8. References.- 9 The Activation of Chemicals into Mutagens by Green Plants.- 1. Introduction.- 2. Plant Activation of Promutagens.- 3. Deactivation of Mutagens by Plants.- 4. Response of Plant Genetic Assays to Known Mammalian Promutagens.- 5. Conclusion.- 6. References.- 10 Unscheduled DNA Synthesis in Mammalian Germ Cells—Its Potential Use in Mutagenicity Testing Gary A. Sega.- 1. Introduction.- 2. What Does the Occurrence of Unscheduled DNA Synthesis in Mouse Germ Cells Mean?.- 3. Procedures for Treating Animals with [3H]Thymidine and Chemical Mutagens.- 4. Detection of Unscheduled DNA Synthesis in the Germ Cells.- 5. Germ-Cell Stages That Undergo Unscheduled DNA Synthesis When Exposed to Mutagenic Agents.- 6. Comparison of the Sensitivity of the Test for Unscheduled DNA Synthesis with That of Other GeneticTests.- 7. Relationship between Genetic Effects and Unscheduled DNA Synthesis Induced by Mutagens.- 8. Development and Characterization of Mouse Stocks with Reduced Levels of Unscheduled DNA Synthesis in Their Germ Cells.- 9. Relevancy of the Test for Mammalian Germ-Cell Unscheduled DNA Synthesis Compared with That of Other Mutagenicity Tests.- 10. References.- 11 Aspergillus nidulans—An Organism for Detecting a Range of Genetic Damage.- 1. Introduction.- 2. Basic Biology.- 3. General Methodology.- 4. Assay Systems.- 5. Concluding Remarks.- 6. References.