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Peptide Research Protocols: Endothelin - Maguire, Janet J. Davenport, Anthony P.
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Maguire, Janet J. Davenport, Anthony P.:
Peptide Research Protocols: Endothelin - hardcover

2002, ISBN: 9780896039933

[ED: Hardcover], [PU: Springer, Berlin], The endothelins are a remarkable family of signaling peptides: molecular biology predicted the existence of their receptors and synthetic enzymes prior to both the identification of the encoded proteins and the synthesis of antagonists and inhibitors for use as pharmacological tools. Although considerable advances have been made, culminating in the design of endothelin antagonists with the- peutic potential in cardiovascular disease, much remains to be discovered. Tantalizingly, new research frontiers are emerging. To support further progress, Peptide Research Protocols: Endothelin encompasses experimental protocols that interrogate all facets of an endogenous mammalian peptide s- tem, from peptide and receptor expression through synthetic pathway to peptide function and potential role in human disease. Chapters describe the use of molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin-converting enzymes. Peptides, precursors, receptors, and synthetic enzymes may be localized and quantified in plasma, culture supernatants, tissue homogenates, and tissue s- tions using antibodies, while additional information on receptor characterization may be obtained using radioligand binding techniques. Several protocols cover in vitro assays that determine the function of the endothelin peptides in isolated preparations, that characterize new endothelin receptor ligands, or provide inf- mation on the tissue-specific processing of endothelin precursor peptides.2002. x, 242 S. 67 SW-Abb., 1 Farbabb., 12 Duoton-Abb., 55 SW-Zeichn. 228 mmVersandfertig in über 4 Wochen, [SC: 0.00]

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Peptide Research Protocols: Endothelin (Methods in Molecular Biology) - Anthony P. Davenport
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ISBN: 9780896039933

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Peptide Research Protocols - Janet J. Maguire; Anthony P. Davenport
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Janet J. Maguire; Anthony P. Davenport:
Peptide Research Protocols - new book

ISBN: 9780896039933

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Pharmacy; Pharmacy Books Book, Springer Science+Business Media

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Peptide Research Protocols - Janet J. Maguire; Anthony P. Davenport
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Janet J. Maguire; Anthony P. Davenport:
Peptide Research Protocols - hardcover

2002, ISBN: 9780896039933

ID: 4405439

Hardcover, Buch, [PU: Humana Press Inc.]

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Peptide Research Protocols 1st Edition - Anthony P  Davenport  Janet J  Maguire
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Details of the book
Peptide Research Protocols: Endothelin

A panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of the endothelin system from its synthesis and metabolism, to its function in health and disease. Theses methods use state-of-the-art molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies. Several in vivo protocols illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function.

Details of the book - Peptide Research Protocols: Endothelin


EAN (ISBN-13): 9780896039933
ISBN (ISBN-10): 0896039935
Hardcover
Publishing year: 2002
Publisher: SPRINGER VERLAG GMBH
242 Pages
Weight: 0,667 kg
Language: eng/Englisch

Book in our database since 18.12.2007 12:23:34
Book found last time on 03.05.2017 09:57:01
ISBN/EAN: 9780896039933

ISBN - alternate spelling:
0-89603-993-5, 978-0-89603-993-3


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