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Improved Non-Steroid Anti-Inflammatory Drugs: Cox-2 Enzyme Inhibitors - Vane, John R. Vane, John Botting, Regina M.
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Vane, John R. Vane, John Botting, Regina M.:
Improved Non-Steroid Anti-Inflammatory Drugs: Cox-2 Enzyme Inhibitors - hardcover

ISBN: 9780792388975

[ED: Hardcover], [PU: SPRINGER VERLAG GMBH], In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.Versandfertig in über 4 Wochen, [SC: 0.00]

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Improved Non-steroid Anti-inflammatory Drugs - Kluwer Academic Publishers
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Kluwer Academic Publishers:
Improved Non-steroid Anti-inflammatory Drugs - new book

ISBN: 9780792388975

ID: 68554b70e09d579aca992da1f90ef591

Improved Non-steroid Anti-inflammatory Drugs This volume contains the proceedings of the William Harvey Conference held in London, 10-11 October, 1995. It covers the molecular biology and physiological functions of the cyclo-oxygenase enzymes, as well as the experimental and clinical aspects of the recently discovered inhibitors of the inducible cyclooxygenase. Particular attention has been directed at the discussion of the selectivity of non-steroid anti-inflammatory drugs for cyclooxygenase-2 and their propensity to cause gastric and kidney damage. Sir John Vane is the Director General, Regina Botting the Information Scientist, and Jack Botting Consultant at the William Harvey Research Institute, an independent charitable foundation carrying out research into cardiovascular disease inflammation and metabolic disorders within Queen Mary and Westfield College of the University of London, UK. Sir John Vane was awarded the Nobel Prize in 1982 for his discoveries of the mechanism of action of aspirin and of the physiological role of prostacyclin and other prostanoids. Bücher 978-0-7923-8897-5, Kluwer Academic Publishers

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Improved Non-Steroid Anti-Inflammatory Drugs: Cox-2 Enzyme Inhibitors - Vane, John R. Vane, Sir John
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Vane, John R. Vane, Sir John:
Improved Non-Steroid Anti-Inflammatory Drugs: Cox-2 Enzyme Inhibitors - hardcover

ISBN: 9780792388975

[ED: Hardcover], [PU: SPRINGER VERLAG GMBH], This volume contains the proceedings of the William Harvey Conference held in London, 10-11 October, 1995. It covers the molecular biology and physiological functions of the cyclo-oxygenase enzymes, as well as the experimental and clinical aspects of the recently discovered inhibitors of the inducible cyclooxygenase. Particular attention has been directed at the discussion of the selectivity of non-steroid anti-inflammatory drugs for cyclooxygenase-2 and their propensity to cause gastric and kidney damage. Sir John Vane is the Director General, Regina Botting the Information Scientist, and Jack Botting Consultant at the William Harvey Research Institute, an independent charitable foundation carrying out research into cardiovascular disease inflammation and metabolic disorders within Queen Mary and Westfield College of the University of London, UK. Sir John Vane was awarded the Nobel Prize in 1982 for his discoveries of the mechanism of action of aspirin and of the physiological role of prostacyclin and other prostanoids.Versandfertig in über 4 Wochen, [SC: 0.00]

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Improved Non-steroid Anti-inflammatory Drugs: COX-2 Enzyme Inhibitors - Edited By Vane,Sir John,Botting,Dr Jack and Regina
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Edited By Vane,Sir John,Botting,Dr Jack and Regina:
Improved Non-steroid Anti-inflammatory Drugs: COX-2 Enzyme Inhibitors - used book

1996, ISBN: 9780792388975

ID: 119511196

London: Kluwer Academic Publishers, 1996. This volume contains the proceedings of the William Harvey Conference held in London, 10-11 October, 1995. It covers the molecular biology and physiological functions of the cyclo-oxygenase enzymes, as well as the experimental and clinical aspects of the recently discovered inhibitors of the inducible cyclooxygenase. Particular attention has been directed at the discussion of the selectivity of non-steroid anti-inflammatory drugs for cyclooxygenase-2 and their propensity to cause gastric and kidney damage. 248pp.. Cloth. As New/No d/j as Published. 8vo - over 7¾" - 9¾" tall., Kluwer Academic Publishers, 1996

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Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors - R. Vane, John and Sir John Vane
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R. Vane, John and Sir John Vane:
Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors - hardcover

1996, ISBN: 0792388976

ID: 246931

Gebundene Ausgabe 200 Seiten Gebundene Ausgabe ex Library Book / aus einer wissenschafltichen Bibliothek /, [PU:Kluwer Academic Publishers,]

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