ISBN: 9780387691336

The field of pharmacogenetics has expanded rapidly over the past few years since the release of the working draft of the human genome project and the continuing efforts of the internation… More...

The field of pharmacogenetics has expanded rapidly over the past few years since the release of the working draft of the human genome project and the continuing efforts of the international HapMap project. Cancer therapy offers an ideal scenario for the integration of pharmacogenetics into clinical practice - often there are multiple treatment options but a finite window of time to select the correct one. The ideal of testing patients for genetic markers for chemotherapy efficacy and/or toxicity is becoming a reality with FDA approved clinical tests and genotype-guided clinical trials. This volume is designed to offer an overview of the role of pharmacogenetics in cancer treatment, from the history of the field through to its integration into clinical practice. Books, Health and Well Being, Cancer Pharmacogenetics Books>Health and Well Being The field of pharmacogenetics has expanded rapidly over the past few years since the release of the working draft of the human genome project and the continuing efforts of the international HapMap project. Cancer therapy offers an ideal scenario for the integration of pharmacogenetics into clinical practice - often there are multiple treatment options but a finite window of time to select the correct one. The ideal of testing patients for genetic markers for chemotherapy efficacy and/or toxicity is becoming a reality with FDA approved clinical tests and genotype-guided clinical trials. This volume is designed to offer an overview of the role of pharmacogenetics in cancer treatment, from the history of the field through to its integration into clinical practice. TOC:A History of Pharmacogenetics.- Pharmacokinetics and pharmacogenetics.- drug targets and pharmacogenetics.- Pharmacodynamics and pharmacogenetics.- toxicity and pharmacogentics.- Leukemia: the TPMT Example.- Solid tumors I: The UGT1A1 Example.- Solid Tumors II: the EGFR Example.- Novel Pharmacogenetic markers: whole genome association studies.- In silico resources for cancer pharmacogenetics: databases and knowledge bases.- pharmacogenetics methodology-overview of available methods.- From bedside to clinical practice I: Clinical trials.- From Bedside to Clinical Practice II: FDA.- The Future of Cancer Pharmacogenetics<

2008, ISBN: 9780387691336

The field of pharmacogenetics has expanded rapidly over the past few years since the release of the working draft of the human genome project and the continuing efforts of the internation… More...

The field of pharmacogenetics has expanded rapidly over the past few years since the release of the working draft of the human genome project and the continuing efforts of the international HapMap project. Cancer therapy offers an ideal scenario for the integration of pharmacogenetics into clinical practice - often there are multiple treatment options but a finite window of time to select the correct one. The ideal of testing patients for genetic markers for chemotherapy efficacy and/or toxicity..., The field of pharmacogenetics has expanded rapidly over the past few years since the release of the working draft of the human genome project and the continuing efforts of the international HapMap project. Cancer therapy offers an ideal scenario for the integration of pharmacogenetics into clinical practice - often there are multiple treatment options but a finite window of time to select the correct one. The ideal of testing patients for genetic markers for chemotherapy efficacy and/or toxicity is becoming a reality with FDA approved clinical tests and genotype-guided clinical trials. This volume is designed to offer an overview of the role of pharmacogenetics in cancer treatment, from the history of the field through to its integration into clinical practice.Taal: Engels; Afmetingen: 235x155 mm; Verschijningsdatum: april 2008; Druk: 1; ISBN10: 0387691332; ISBN13: 9780387691336; , Engelstalig | Hardcover | 2008, Studie & Management, Medisch & Gezondheid, Bewegingswetenschappen, Studie & Management, Exacte wetenschappen, Biologie, Studie & Management, Medisch & Gezondheid, Farmacologie, Studie & Management, Medisch & Gezondheid, Geneeskunde, Gezondheid & Psychologie, Therapie & Zelfhulp, Gezondheid & Psychologie, Ziekten & Stoornissen, Springer-Verlag New York Inc.<