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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy - Stephen B. Howell
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Stephen B. Howell:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy - used book

ISBN: 030644027X

ID: 5987871

Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV- induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials basic sciences,biochemistry,biological sciences,biology and life sciences,clinical,immunology,internal medicine,medical,medical books,medicine Clinical, Springer

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy - Howell, Stephen B. (Hrsg.)
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Howell, Stephen B. (Hrsg.):
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy - hardcover

ISBN: 9780306440274

[ED: Hardcover], [PU: Springer, Berlin], Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and -DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.xii, 546 S. 32 SW-Abb.,. 234 mmVersandfertig in 3-5 Tagen, [SC: 0.00]

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Proceedings of the Sixth International Symposium on Platinum and OtherMetal Coordination Compounds in Cancer Chemotherapy, Held January 23-26, 1991, in San Diego, California - Stephen B. Howell
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Stephen B. Howell:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Proceedings of the Sixth International Symposium on Platinum and OtherMetal Coordination Compounds in Cancer Chemotherapy, Held January 23-26, 1991, in San Diego, California - hardcover

ISBN: 9780306440274

Hardback, [PU: Springer Science+Business Media], papers from the January 1991 symposium are presented in sections on synthetic chemistry and biochemistry, biochemical and molecular pharmacology, toxicology and clinical pharmacology of new drugs, and clinical trials. Some specific topics: modelling platinum-DNA interactions; structurally novel plat, Oncology

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy - Stephen B. Howell
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Stephen B. Howell:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy - hardcover

1992, ISBN: 9780306440274

ID: 1918579

Hardcover, Buch, [PU: Plenum Publishing Co.,N.Y.]

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 1st Edition - Stephen B  Howell
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Stephen B Howell:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 1st Edition - new book

ISBN: 9780306440274

ID: 423426663

NA Cancer, Chemotherapy, Metal, Springer

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