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Proteasome Inhibitors in Cancer Therapy - Julian Adams (Editor)
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Proteasome Inhibitors in Cancer Therapy - used book

ISBN: 9781617374524

ID: 9781617374524

Immediately upon the discovery some ten years ago that inhibition of the proteasome in cultured cells, mostly of tumor origin, caused the programmed cell death machinery to ramp up, it became imperative to investigate proteasome inhibition as a possible treatment for human cancers. In Proteasome Inhibitors in Cancer Therapy, Julian Adams, the leader in developing the field, brings together a panel of highly experienced academic and pharmaceutical investigators to take sk of the remarkable Immediately upon the discovery some ten years ago that inhibition of the proteasome in cultured cells, mostly of tumor origin, caused the programmed cell death machinery to ramp up, it became imperative to investigate proteasome inhibition as a possible treatment for human cancers. In Proteasome Inhibitors in Cancer Therapy, Julian Adams, the leader in developing the field, brings together a panel of highly experienced academic and pharmaceutical investigators to take sk of the remarkable work that has been accomplished to date, and examine emerging therapeutic possibilities for proteasome inhibitors in cancer. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of the very empirical and practical development of rationales to test proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of proteasome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (Velcade™) through multicentered clinical trials in patients with relapsed and refractory myeloma to FDA approval, and describe how modern pharmacogenomic tools can be used to predict which patients will respond to such proteasome inhibitor therapy. Additional chapters on the proteasome's basic biochemistry review its mechanism in the cell cycle and apoptosis and suggest opportunities for using proteasome inhibitors to find additional medicinal targets. Authoritative and illuminating, Proteasome Inhibitors in Cancer Therapy makes clear that proteasome inhibition should prove a fertile area for the many future discoveries that will provide relief of suffering and extend the quality of life of patients afflicted Books, Medicine~~Oncology, Proteasome-Inhibitors-in-Cancer-Therapy~~Julian-Adams, 999999999, Proteasome Inhibitors in Cancer Therapy, Julian Adams (Editor), 1617374520, Springer-Verlag New York, LLC, , , , , Springer-Verlag New York, LLC

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Proteasome Inhibitors in Cancer Therapy - Herausgegeben von Adams, Julian
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Herausgegeben von Adams, Julian:
Proteasome Inhibitors in Cancer Therapy - Paperback

2010, ISBN: 9781617374524

[ED: Softcover], [PU: Springer, Berlin], A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (Velcade(TM)) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.2010. 328 S. 88 SW-Abb., 8 Farbabb. 254 mmVersandfertig in 3-5 Tagen, [SC: 0.00]

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Proteasome Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) - Julian Adams (Editor)
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Julian Adams (Editor):
Proteasome Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) - Paperback

ISBN: 1617374520

ID: 11806453050

[EAN: 9781617374524], Neubuch, [PU: Humana Press]

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Proteasome Inhibitors in Cancer Therapy - Julian Adams
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Julian Adams:
Proteasome Inhibitors in Cancer Therapy - Paperback

2010, ISBN: 9781617374524

Hardcover, ID: 16168420

Softcover reprint of hardcover 1st ed. 2004, Softcover, Buch, [PU: Humana Press Inc.]

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Proteasome Inhibitors in Cancer Therapy - Julian Adams
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Julian Adams:
Proteasome Inhibitors in Cancer Therapy - Paperback

2010, ISBN: 9781617374524

ID: 16168420

1st ed. Softcover of orig. ed. 2004, Softcover, Buch, [PU: Humana Press Inc.]

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Details of the book
Proteasome Inhibitors in Cancer Therapy

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (Velcade(TM)) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

Details of the book - Proteasome Inhibitors in Cancer Therapy


EAN (ISBN-13): 9781617374524
ISBN (ISBN-10): 1617374520
Hardcover
Paperback
Publishing year: 2010
Publisher: Springer-Verlag GmbH
328 Pages
Weight: 0,691 kg
Language: eng/Englisch

Book in our database since 29.09.2011 10:13:21
Book found last time on 15.10.2017 13:50:24
ISBN/EAN: 1617374520

ISBN - alternate spelling:
1-61737-452-0, 978-1-61737-452-4


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