ISBN: 9780470029565

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remai… More...

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on other ion channels are offered in the discussions, which make fascinating reading. This family consists of at least 10 genes, each of which has several splice variants. Most members of the family are expressed in the luminal membrane of epithelial cells. Characterization of anion transport by three members has revealed that all function as Cl-/HCO3- exchangers, suggesting that SLC26 transporters are responsible for the luminal Cl-/HCO3- exchange activity. The SLC26 transporters are activated by the CF transmembrane conductance regulator and activate it in turn, leading to a model in which these molecules act together to mediate epithelial Cl- absorption and HCO3- secretion. The book includes chapters on the transport of other molecules by the SLC26 family, including oxalate in the kidney and sugars in cochlear hair cells amongst others. It also describes recent discoveries that most SLC26 transporters bind to scaffold proteins and that they all contain a conserved domain predicted to participate in protein-protein interactions. These suggest the SLC26 transporters exist in complexes with other Cl- and HCO3- transporters, and possibly other regulatory proteins. This book explores the functional role of these interactions, leading to better understanding of transepithelial fluid and electrolyte secretion and the diseases associated with it.; PDF; Scientific, Technical and Medical > Pre-clinical medicine: basic sciences > Medical genetics, Wiley<

2006, ISBN: 9780470029565

The Role of the SLC26 Transporters Family, eBooks, eBook Download (PDF), 1. Auflage, Cl- absorption and HCO3- secretion are intimately associatedprocesses vital to epithelial function, it… More...

The Role of the SLC26 Transporters Family, eBooks, eBook Download (PDF), 1. Auflage, Cl- absorption and HCO3- secretion are intimately associatedprocesses vital to epithelial function, itself a key physiologicalactivity. Until recently the transporters responsible remainedobscure, but a breakthrough occurred with the discovery of theSLC26 transporters family. It is now clear that the SLC26transporters have broad physiological functions since mutations inseveral members are linked to a variety of diseases. This bookdescribes the properties of this family in detail, withcontributions from the leading global researchers in the field.Complementary views from experts on other ion channels are offeredin the discussions, which make fascinating reading. This family consists of at least 10 genes, each of which hasseveral splice variants. Most members of the family are expressedin the luminal membrane of epithelial cells. Characterization ofanion transport by three members has revealed that all function asCl-/HCO3- exchangers, suggesting that SLC26 transporters areresponsible for the luminal Cl-/HCO3- exchange activity. The SLC26transporters are activated by the CF transmembrane conductanceregulator and activate it in turn, leading to a model in whichthese molecules act together to mediate epithelial Cl- absorptionand HCO3- secretion. The book includes chapters on the transport of other molecules bythe SLC26 family, including oxalate in the kidney and sugars incochlear hair cells amongst others. It also describes recentdiscoveries that most SLC26 transporters bind to scaffold proteinsand that they all contain a conserved domain predicted toparticipate in protein-protein interactions. These suggest theSLC26 transporters exist in complexes with other Cl- and HCO3-transporters, and possibly other regulatory proteins. This bookexplores the functional role of these interactions, leading tobetter understanding of transepithelial fluid and electrolytesecretion and the diseases associated with it. [PU: John Wiley & Sons], Seiten: 284, John Wiley & Sons, 2006<

ISBN: 9780470029565

*Epithelial Anion Transport in Health and Disease* - The Role of the SLC26 Transporters Family / pdf eBook für 161.99 € / Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Wissenschafte… More...

*Epithelial Anion Transport in Health and Disease* - The Role of the SLC26 Transporters Family / pdf eBook für 161.99 € / Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Wissenschaften, allgemein Medien > Bücher nein eBook als pdf eBooks > Fachthemen & Wissenschaft > Wissenschaften allgemein, John Wiley & Sons<

2006, ISBN: 9780470029565

The Role of the SLC26 Transporters Family, eBooks, eBook Download (PDF), 1. Auflage, [PU: Wiley], Wiley, 2006