Bioprocess Technology: Kinetics and Reactors - hardcover

EAN (ISBN-13): 9780387966038
ISBN (ISBN-10): 038796603X
Hardcover
Paperback
Publishing year: 1988
Publisher: Springer

Book in our database since 2007-05-01T07:07:53-04:00 (New York)
Detail page last modified on 2023-11-17T01:17:32-05:00 (New York)
ISBN/EAN: 038796603X

ISBN - alternate spelling:
0-387-96603-X, 978-0-387-96603-8
Alternate spelling and related search-keywords:
Book author: anton moser, anton möser
Book title: bioprocess technology

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Information from Publisher

Author: Anton Moser
Title: Bioprocess Technology - Kinetics and Reactors
Publisher: Springer; Springer US
451 Pages
Publishing year: 1998-02-20
New York; NY; US
Translator: Philip Manor (German)
Weight: 0,840 kg
Language: English
85,55 € (DE)
87,95 € (AT)
106,60 CHF (CH)
Not available, publisher indicates OP

BB; Book; Hardcover, Softcover / Biologie/Genetik, Gentechnik; Biotechnologie; Verstehen; transport; photosynthesis; flow; food; growth; Fermenter; heat transfer; reaction; biotechnology; metabolism; enzymes; Fermentation; viscosity; water; thermodynamics; C; Biotechnology; Chemistry and Materials Science; Industrial Chemistry/Chemical Engineering; Industrielle Chemie und Chemietechnologie; BC; EA

1 Introduction.- 1.1 Biotechnology: A Definition and Overview.- 1.2 Bioprocess Technology.- 2 The Principles of Bioprocess Technology.- 2.1 Empirical Pragmatic Process Development.- 2.1.1 Production Strains.- 2.1.2 Starting Points.- 2.1.3 Different Modes (or Strategies) in Process Development.- 2.1.4 Process Development Without Mathematical Models.- 2.2 Basics of Quantification Methods for Bioprocesses.- 2.2.1 Concepts of a Uniform Nomenclature for Bioprocess Kinetics.- 2.2.2 The Rates of a Bioprocess.- 2.2.3 Stoichiometry and Thermodynamics.- 2.2.4 Productivity, Conversion, and Economics (Profit).- 2.3 Systematic, Empirical Process Development with Mathematical Models.- 2.3.1 An Integrating Strategy—A Basis for Biotechnological Methodology.- 2.3.2 Working Principles of Bioprocess Technology.- 2.4 Mathematical Modeling in Bioprocessing.- 2.4.1 General Remarks.- 2.4.2 Model Building.- 2.4.3 Different Levels and Types of Kinetic Models.- 3 Bioreactors.- 3.1 Overview: Industrial Reactors.- 3.1.1 Microbiological Reactors (Fermenters, Cell Tissue Culture Vessels, and Waste Water Treatment Plants).- 3.1.2 Enzyme Reactors.- 3.1.3 Sterilizers.- 3.2 Systematics of Bioreactors.- 3.2.1 Homogeneous Versus Heterogeneous Systems.- 3.2.2 Mixing Behavior.- 3.3 Quantification Methods.- 3.3.1 Residence Time Distribution (RTD)—Macromixing.- 3.3.2 Micromixing.- 3.3.3 Oxygen Transfer Rate (OTR).- 3.3.4 Degree of O2 Utilization, $${\\eta _{{O_2}}}$$.- 3.3.5 Degree of Hinterland, Hl.- 3.3.6 Power Consumption, P.- 3.3.7 O2 Efficiency (Economy) $${E_{{O_2}}}$$.- 3.3.8 Heat Transfer Rate, HvTR.- 3.3.9 Characteristic Diameter of Biocatalytic Mass $${\\bar d_p}$$.- 3.3.10 Comparison of Process Technology Data for Bioreactors.- 3.3.11 Biological Test Systems.- 3.4 Operational Modes and Bioreactor Concepts.- 3.5 Bioreactor Models.- 3.5.1 Model 1: The Ideal Discontinuous Stirred Tank Reactor (DCSTR).- 3.5.2 Model 2: The Ideal Continuous Stirred Tank Reactor (CSTR) with V = Constant.- 3.5.3 Model 3: The Ideal Semicontinuous Stirred Tank Reactor (SCSTR) with V = Variable.- 3.5.4 Model 4: The Ideal Continuous Plug Flow Reactor (CPFR) or Tubular Reactor.- 3.5.5 Model 5: The Real Plug Flow Reactor CPFR with Dispersion.- 3.5.6 Model 6: The Discontinuous Recycle Reactor (DCRR).- 3.5.7 Model 7: The Continuous Recycle Reactor (CRR).- 3.5.8 Multiple Phase Bioreactor Models.- 3.6 “Perfect Bioreactors” in Bench and Pilot Scale for Process Kinetic Analysis.- 4 Process Kinetic Analysis.- 4.1 Kinetic Analysis in Different Types of Reactors.- 4.2 Regime Analysis—General Concept and Guidelines.- 4.3 Test of Pseudohomogeneity.- 4.4 Parameter Estimation of Kinetic Models with Bioreactors.- 4.4.1 Integral and Differential Reactors.- 4.4.2 Integral and Differential Reactor Data Evaluation Methods.- 4.4.3 Results of Differential and Integral Analysis: Linearization Diagrams.- 4.5 Modeling Heterogeneous Processes.- 4.5.1 External Transport Limitations.- 4.5.2 Internal Transport Limitations.- 4.5.3 Combined Internal and External Transport Limitations.- 4.5.4 Transport Enhancement.- 4.5.5 Concluding Remarks.- 5 Bioprocess Kinetics.- 5.1 Temperature Dependence, k(T), Water Activity, aw, and Enthalpy/Entrophy Compensation.- 5.2 Microkinetic Equations Derived from the Kinetics of Chemical and Enzymatic Reactions.- 5.2.1 The Dynamic Flow Equilibrium Approach to Life Processes.- 5.2.2 Contribution of Enzyme Mechanism to Bioprocess Kinetic Models.- 5.2.3 Contribution of Chemical Kinetic Laws to Bioprocess Kinetic Modeling.- 5.3 Basic Unstructured Kinetic Models of Growth and Substrate Utilization (Homogeneous Rate Equations).- 5.3.1 µ = µ(s): Simple Model Functions of Inhibition-Free Substrate Limitation (Saturation-Type Kinetics).- 5.3.2 µ = µ(x): Influence of Biomass Concentration on Specific Growth Rate.- 5.3.3 µ = µ(t): Extensions of Monod-Type Kinetics to Stationary and Lag Phase.- 5.3.4 Negative Biokinetic Rates—The Case of Microbial Death and Endogenous Metabolism.- 5.3.5 Kinetic Model Equations for Inhibition by Substrates and Products.- 5.3.6 Kinetic Model Equations for Repression.- 5.3.7 µ = µ(pH).- 5.3.8 Kinetic Pseudohomogeneous Modeling of Mycelial Filamentous Growth Including Photosynthesis.- 5.3.9 Kinetic Modeling of Biosorption.- 5.4 Kinetic Models for Microbial Product Formation.- 5.4.1 Metabolites and End Products.- 5.4.2 Heat Production in Fermentation Processes.- 5.5 Multisubstrate Kinetics.- 5.5.1 Sequential Substrate-Utilization Kinetics.- 5.5.2 Simultaneous Substrate-Utilization Kinetics.- 5.5.3 Generalizations in Multisubstrate Kinetics.- 5.6 Mixed Population Kinetics.- 5.6.1 Classification of the Types of Microbial Interactions.- 5.6.2 Kinetic Analysis of Microbial Interactions.- 5.7 Dynamic Models for Transient Operation Techniques (Nonstationary Kinetics).- 5.7.1 Definitions of Balanced Growth and Steady-State Growth.- 5.7.2 Mathematical Modeling of Dynamic Process Kinetics.- 5.8 Kinetic Models of Heterogeneous Bioprocesses.- 5.8.1 Biofilm Kinetics.- 5.8.2 Unstructured Models of Pellet Growth.- 5.8.3 Linear Growth.- 5.9 Pseudokinetics.- 5.10 Kinetics of Sterilization.- 5.10.1 Basic Kinetic Approaches in Sterilization Kinetics.- 5.10.2 Multicomponent Systems in Food Technology.- 6 Bioreactor Performance: Process Design Methods.- 6.1 The Ideal Single-Stage, Constant-Volume Continuous Stirred Tank Reactor, CSTR (Pseudohomogeneous L-Phase Reactor Model).- 6.1.1 Performance of the CSTR with Simple Kinetics.- 6.1.2 Performance of the CSTR with Complex Kinetics.- 6.1.3 Stability Analysis and Transient Behavior of the CSTR.- 6.2 Variable Volume CSTR Operation (Fed-Batch and Transient Reactor Operation).- 6.3 Multistage Single and Multistream Continuous Reactor Operation..- 6.3.1 Classification.- 6.3.2 Potentialities of Multistage Systems.- 6.3.3 Single-Stream Multistage Operation.- 6.3.4 Multistream Multistage Operation.- 6.4 Continuous Plug Flow Reactors (CPFR).- 6.4.1 Performance Equations.- 6.4.2 Potential Advantages of CPFR Operation.- 6.4.3 Principal Properties and Design of CPFRs Compared with CSTRs.- 6.4.4 Applications of CPFR.- 6.4.5 One-Phase (Liquid) Reactors with Arbitrary Residence Time Distribution and Micromixing.- 6.5 Recycle Reactor Operation.- 6.5.1 Performance Equations of Recycle Reactors.- 6.5.2 Application of CRR.- 6.6 Gas/Liquid (Two-Phase) Reactor Models in Bioprocessing.- 6.7 Biofilm Reactor Operation.- 6.7.1 Potentialities of Biofilm Reactors.- 6.7.2 Performance Equations of Biofilm Reactors.- 6.7.3 Application of Biofilm Reactors.- 6.8 Dialysis and Synchronous Culture Operation.- 6.8.1 Dialysis (Membrane) Reactor Operation.- 6.8.2 Synchronous Culture Operation.- 6.9 Integrating Strategy as General Scale-Up Concept in Bioprocessing.- 6.9.1 Stoichiometry (Balancing Methods) Applied in Bioprocess Design.- 6.9.2 Interactions Between Biology and Physics via Viscosity of Fermentation Media.- 6.9.3 Influence of Mycelium—The Morphology Factors (“Apparent Morphology”).- 6.9.4 Structured Modeling of Bioreactors (OTR).- 6.10 Final Note.- Appendix I Fundamentals of Stoichiometry of Complex Reaction Systems.- Appendix II Computer Simulations.- Appendix III Microkinetics: Derivation of Kinetic Rate Equations from Mechanisms.