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Chemical Carcinogenesis
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Chemical Carcinogenesis - new book

ISBN: 9781617379949

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many ca… More...

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Chemical Carcinogenesis (Current Cancer Research) - Penning
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Chemical Carcinogenesis (Current Cancer Research) - hardcover

2011, ISBN: 9781617379949

[ED: Gebundene Ausgabe], [PU: Springer], EAN: 9781617379949 Das Titelbild der Auflage kann abweichen. Buch mit Gebrauchsspuren und vereinzelten Knicken, Flecken oder mit Gebrauchsspuren a… More...

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Chemical Carcinogenesis - Penning, Trevor M.
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Penning, Trevor M.:
Chemical Carcinogenesis - hardcover

2011

ISBN: 9781617379949

[ED: Gebunden], [PU: Humana Press], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Focuses of this volume: chemical carcinogenesis, expos… More...

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Chemical Carcinogenesis (Current Cancer Research) - Penning
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Penning:
Chemical Carcinogenesis (Current Cancer Research) - hardcover

2011, ISBN: 9781617379949

Springer, Hardcover, Auflage: 2011, 456 Seiten, Publiziert: 2011-03-03T00:00:01Z, Produktgruppe: Book, 0.85 kg, Verkaufsrang: 10885413, Oncology, Internal Medicine, Medicine, Medical Book… More...

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Chemical Carcinogenesis - Penning, Trevor M. (Herausgeber)
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Penning, Trevor M. (Herausgeber):
Chemical Carcinogenesis - hardcover

2011, ISBN: 1617379948

2011 Gebundene Ausgabe Krebs (Krankheit), Tumor / Krebs, Arznei / Arzneimittellehre, Pharmakologie, Toxikologie, Pharmacology, Cancer; cancerresearch, mit Schutzumschlag 11, [PU:Humana … More...

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Bibliographic data of the best matching book

Details of the book
Chemical Carcinogenesis (Current Cancer Research)
Author:
Title:
ISBN:

9781617379949


This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Details of the book - Chemical Carcinogenesis (Current Cancer Research)


EAN (ISBN-13): 9781617379949
ISBN (ISBN-10): 1617379948
Hardcover
Publishing year: 2011
Publisher: Springer
440 Pages
Weight: 0,809 kg
Language: eng/Englisch

Book in our database since 2007-05-02T22:55:00-04:00 (New York)
Detail page last modified on 2024-03-07T05:47:00-05:00 (New York)
ISBN/EAN: 9781617379949

ISBN - alternate spelling:
1-61737-994-8, 978-1-61737-994-9
Alternate spelling and related search-keywords:
Book author: penning, trevor

Information from Publisher

Author: Trevor M. Penning
Title: Current Cancer Research; Chemical Carcinogenesis
Publisher: Humana; Humana Press
440 Pages
Publishing year: 2011-03-03
Totowa; NJ; US
Printed / Made in
Weight: 0,846 kg
Language: English
235,39 € (DE)
241,99 € (AT)
260,00 CHF (CH)
POD
XVI, 440 p. With 2 16 page color inserts.

BB; Cancer Research; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Onkologie; Verstehen; Cancer; Cancer Research; Carcinogenesis; Chemical; Pharmacology/Toxicology; Cancer Biology; Pharmacology; Pharmakologie; BC; EA

This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.

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