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Target Pattern Recognition in Innate Immunity - Uday Kishore
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Uday Kishore:

Target Pattern Recognition in Innate Immunity - new book

2010, ISBN: 9781441909015

ID: 689056500

Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events.The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipidsand the subsequent interaction of the bound CR P with C1qto give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganismsto give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells.In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune systemand to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms. This volume examines the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. eBooks > Fremdsprachige eBooks > Englische eBooks > Sach- & Fachthemen PDF 01.01.2010, Springer New York, .201

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Target Pattern Recognition in Innate Immunity - Uday Kishore
book is out-of-stock
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Uday Kishore:

Target Pattern Recognition in Innate Immunity - new book

ISBN: 9781441909015

ID: 125775411

Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events.The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipidsand the subsequent interaction of the bound CR P with C1qto give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganismsto give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells.In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune systemand to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms. This volume examines the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. eBook eBooks>Fremdsprachige eBooks>Englische eBooks>Sach- & Fachthemen, Springer New York

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Target Pattern Recognition in Innate Immunity
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Target Pattern Recognition in Innate Immunity - new book

2009

ISBN: 9781441909015

ID: 712715181

Target Pattern Recognition in Innate Immunity:2009. Auflage Target Pattern Recognition in Innate Immunity:2009. Auflage eBooks > Fachthemen & Wissenschaft > Medizin, Springer New York

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Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology, Vol 653 - Uday Kishore
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Uday Kishore:
Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology, Vol 653 - First edition

2009, ISBN: 9781441909015

ID: 21681847

[ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Springer-Verlag]

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Target Pattern Recognition in Innate Immunity - Uday Kishore;  Uday Kishore
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Uday Kishore; Uday Kishore:
Target Pattern Recognition in Innate Immunity - First edition

2010, ISBN: 9781441909015

ID: 21681847

[ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Springer-Verlag]

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Details of the book
Target Pattern Recognition in Innate Immunity
Author:

Kishore, Uday

Title:

Target Pattern Recognition in Innate Immunity

ISBN:

9781441909015

Details of the book - Target Pattern Recognition in Innate Immunity


EAN (ISBN-13): 9781441909015
Publishing year: 2010
Publisher: Springer New York
222 Pages
Language: eng/Englisch

Book in our database since 13.08.2009 19:12:33
Book found last time on 13.01.2017 12:06:32
ISBN/EAN: 9781441909015

ISBN - alternate spelling:
978-1-4419-0901-5

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