2012, ISBN: 9789400743519

eBooks, eBook Download (PDF), 2012, The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein fold… More...

eBooks, eBook Download (PDF), 2012, The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as 'ER stress'. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases. [PU: Springer Netherlands], Seiten: 452, Springer Netherlands, 2012<

ISBN: 9789400743519

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and… More...

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases., Springer<

2012, ISBN: 9789400743519

Springer, Kindle Ausgabe, Auflage: 2012, 936 Seiten, Publiziert: 2012-08-13T00:00:00.000Z, Produktgruppe: Digital Ebook Purchas, Medizin, Kategorien, Bücher, Immunologie, Grundlagen, Medi… More...

Springer, Kindle Ausgabe, Auflage: 2012, 936 Seiten, Publiziert: 2012-08-13T00:00:00.000Z, Produktgruppe: Digital Ebook Purchas, Medizin, Kategorien, Bücher, Immunologie, Grundlagen, Medizin & Gesundheitsdienste, Fachbücher, Molekularbiologie, Biologie, Biowissenschaften, Naturwissenschaften & Technik, Zellbiologie, Fremdsprachige Bücher, Fremdsprachige eBooks, Kindle eBooks, Kindle-Shop, Wissenschaft & Natur, Englische eBooks, Nach Sprache, Format: Kindle eBook, Agostinis, Patrizia, Afshin, Samali, Springer, 2012<

ISBN: 9789400743519

This book explores the pathophysiology of ER stress, covering its molecular bases, the emerging relevance of ER-mitochondria cross-talk, signaling pathways and cellular responses, includi… More...

This book explores the pathophysiology of ER stress, covering its molecular bases, the emerging relevance of ER-mitochondria cross-talk, signaling pathways and cellular responses, including the adaptive Unfolded Protein Response, autophagy and cell death.; ; Scientific, Technical and Medical > Medicine: general issues > Medical equipment & techniques > Medi; GBP<

ISBN: 9789400743519

Endoplasmic Reticulum Stress in Health and Disease: ab 149.99 € eBooks > Fachthemen & Wissenschaft > Wissenschaften allgemein Springer-Verlag GmbH eBook als pdf, Springer-Verlag GmbH